The association of insulin-like-growth factor 1 (IGF-1) with incident coronary heart disease in women: findings from the prospective British Women's Heart and Health Study.

Abstract

OBJECTIVE:

To examine the association of insulin-like-growth factor 1 (IGF-1) with coronary heart disease (CHD) in women.

METHODS:

Prospective (4 year) case-control study nested within the British Women's Heart and Health Study. With 167 cases and 333 controls. Serum IGF-1 concentrations (on serum stored at -80 degrees C for a median of 4 years) were determined using a two-site immunoenzymometric assay.

RESULTS:

Among both cases and controls IGF-1 was inversely correlated with waist:hip ratio, fasting insulin, HOMA-IR, CRP, triglyceride levels and systolic blood pressure, and was positively correlated with HDL-C levels. The confounder-adjusted (age, socioeconomic position, smoking and physical activity) relative risk ratio for a 1 standard deviation (S.D.) increase in IGF-1 was 0.92 (95% CI: 0.75, 1.12) and additional adjustment for metabolic risk factors (waist:hip ratio, systolic blood pressure, high-density lipoprotein cholesterol, triglycerides, glucose, insulin and C-reactive protein) attenuated this to 0.98 (95% CI: 0.80, 1.21). There was no evidence of non-linear associations and the risk of CHD was similar across quarters of the distribution of IGF-1.

CONCLUSIONS:

Despite associations with established CHD risk factors in this, and other studies, our findings suggest that higher IGF-1 levels are not associated with CHD in older British women. The contradictory evidence to date in this area highlights the need for further large-scale prospective studies and use of genetic epidemiology studies to determine the nature of the association between IGF-1 and CHD.

• Authors: Debbie A Lawlor, Shah Ebrahim, George Davey Smith, Lynne Cherry, Pauline Watt, Naveed Sattar
• Journal: Atherosclerosis (Atherosclerosis) Vol. 201 Issue 1 Pg. 198-204 (Nov 2008) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 18295769 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Lipids
• Insulin-Like Growth Factor I
• C-Reactive Protein

Topics

• Age Factors
• Aged
• Blood Glucose (metabolism)
• Blood Pressure
• C-Reactive Protein (metabolism)
• Case-Control Studies
• Cohort Studies
• Coronary Disease (blood, diagnosis, epidemiology)
• Female
• Humans
• Incidence
• Insulin-Like Growth Factor I (metabolism)
• Lipids (blood)
• Middle Aged
• Risk Factors
• United Kingdom