Abstract | OBJECTIVE: METHODS: Prospective (4 year) case-control study nested within the British Women's Heart and Health Study. With 167 cases and 333 controls. Serum IGF-1 concentrations (on serum stored at -80 degrees C for a median of 4 years) were determined using a two-site immunoenzymometric assay. RESULTS: Among both cases and controls IGF-1 was inversely correlated with waist:hip ratio, fasting insulin, HOMA-IR, CRP, triglyceride levels and systolic blood pressure, and was positively correlated with HDL-C levels. The confounder-adjusted (age, socioeconomic position, smoking and physical activity) relative risk ratio for a 1 standard deviation (S.D.) increase in IGF-1 was 0.92 (95% CI: 0.75, 1.12) and additional adjustment for metabolic risk factors (waist:hip ratio, systolic blood pressure, high-density lipoprotein cholesterol, triglycerides, glucose, insulin and C-reactive protein) attenuated this to 0.98 (95% CI: 0.80, 1.21). There was no evidence of non-linear associations and the risk of CHD was similar across quarters of the distribution of IGF-1. CONCLUSIONS: Despite associations with established CHD risk factors in this, and other studies, our findings suggest that higher IGF-1 levels are not associated with CHD in older British women. The contradictory evidence to date in this area highlights the need for further large-scale prospective studies and use of genetic epidemiology studies to determine the nature of the association between IGF-1 and CHD.
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Authors | Debbie A Lawlor, Shah Ebrahim, George Davey Smith, Lynne Cherry, Pauline Watt, Naveed Sattar |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 201
Issue 1
Pg. 198-204
(Nov 2008)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 18295769
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Lipids
- Insulin-Like Growth Factor I
- C-Reactive Protein
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Topics |
- Age Factors
- Aged
- Blood Glucose
(metabolism)
- Blood Pressure
- C-Reactive Protein
(metabolism)
- Case-Control Studies
- Cohort Studies
- Coronary Disease
(blood, diagnosis, epidemiology)
- Female
- Humans
- Incidence
- Insulin-Like Growth Factor I
(metabolism)
- Lipids
(blood)
- Middle Aged
- Risk Factors
- United Kingdom
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