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Radioprotective properties of eckol against ionizing radiation in mice.

Abstract
We have investigated the radioprotective efficacy of eckol, a component of brown seaweed Ecklonia cava, against the gamma ray-induced damage in vivo. Our results showed that eckol significantly decreased the mortality of lethally irradiated mice. The mechanisms of eckol's protection were found to include: an improvement in hematopoietic recovery, the repair of damaged DNA in immune cells and an enhancement of their proliferation, which had been severely suppressed by ionizing radiation. Thus, we propose eckol as a candidate for adjuvant therapy to alleviate radiation-induced injuries to cancer patients.
AuthorsEunjin Park, Gin-nae Ahn, Nam Ho Lee, Jeong Mi Kim, Jin Seok Yun, Jin Won Hyun, You-Jin Jeon, Myung Bok Wie, Young Jae Lee, Jae Woo Park, Youngheun Jee
JournalFEBS letters (FEBS Lett) Vol. 582 Issue 6 Pg. 925-30 (Mar 19 2008) ISSN: 0014-5793 [Print] Netherlands
PMID18294966 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Dioxins
  • Radiation-Protective Agents
  • eckol
Topics
  • Animals
  • B-Lymphocytes (drug effects, radiation effects)
  • Cell Proliferation (drug effects)
  • DNA Damage (drug effects)
  • Dioxins (chemistry, pharmacology, therapeutic use)
  • Gamma Rays
  • Hematopoiesis (drug effects, radiation effects)
  • Mice
  • Mice, Inbred Strains
  • Radiation Injuries, Experimental (prevention & control)
  • Radiation-Protective Agents (chemistry, pharmacology, therapeutic use)
  • Spleen (drug effects, radiation effects)
  • T-Lymphocytes (drug effects, radiation effects)

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