Do polymorphisms in ABC transporter genes influence risk of childhood acute lymphoblastic leukemia?

Abstract

It is widely accepted that pathogenesis of childhood acute lymphoblastic leukemia (ALL) is related to the interplay between specific environmental exposure and inherited background. Major role of some members of the ATP-binding cassette (ABC) family of membrane transporters including MDR1 (ABCB1, P-glycoprotein) and breast cancer resistant protein (BCRP, ABCG2) is protection against environmental toxins. Here, we review several recent reports on potential association between single nucleotide polymorphisms (SNPs) in genes encoding for ABC transporters with predisposition to pediatric ALL.

• Authors: Krzysztof Jamroziak, Tadeusz Robak
• Journal: Leukemia research (Leuk Res) Vol. 32 Issue 8 Pg. 1173-5 (Aug 2008) ISSN: 0145-2126 [Print] England
• PMID: 18294687 (Publication Type: Journal Article, Comment)

Chemical References

• ATP Binding Cassette Transporter, Subfamily B, Member 1
• ATP-Binding Cassette Transporters

Topics

• ATP Binding Cassette Transporter, Subfamily B, Member 1 (genetics)
• ATP-Binding Cassette Transporters (genetics)
• Child
• Child, Preschool
• Genetic Predisposition to Disease
• Humans
• Polymorphism, Single Nucleotide
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics)