Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia.

Abstract

We report a case of T-cell prolymphocytic leukemia (T-PLL) in a 41-year-old male. Classical cytogenetic, spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH) studies of a blood sample obtained at diagnosis revealed the co-existence of t(X;14)(q28;q11), t(Y;14)(q12;q11) and a ring chromosome derived from i(8)(q10). Immunophenotypic studies revealed involvement of T-cell lineage, with proliferation of CD4(-) CD8+. The co-existence of two translocations involving both sex chromosomes in a case of T-PLL is rare. Chromosomal instability associated with the disease progression may have allowed the emergence of cell clones with translocations involving the sex chromosomes and the ring chromosome observed.

• Authors: F M de Oliveira, L G Tone, B P Simões, E M Rego, A F Marinato, R H Jácomo, R P Falcão
• Journal: International journal of laboratory hematology (Int J Lab Hematol) Vol. 31 Issue 4 Pg. 453-6 (Aug 2009) ISSN: 1751-553X [Electronic] England
• PMID: 18294235 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Chromosomal Instability (genetics)
• Chromosomes, Human, Pair 14 (genetics)
• Chromosomes, Human, X (genetics)
• Chromosomes, Human, Y (genetics)
• Humans
• Leukemia, Prolymphocytic, T-Cell (genetics)
• Male
• Ring Chromosomes
• Spectral Karyotyping
• Translocation, Genetic