Abstract | BACKGROUND:
Melanoma is a tumour that is usually resistant to systemic therapy. Since it has been considered to be a highly immunogenic tumour, it has become an excellent target for the active specific immunotherapy. Vaccine therapy represents a novel approach to the treatment of melanoma. OBJECTIVE: METHODS: Systematic review of the published evidence on vaccine therapy in melanoma. RESULTS: CONCLUSION: Vaccine therapy still remains an experimental therapy in patients with metastatic melanoma. Further research is required although a future therapy for advanced melanoma is probably a multimodal approach including vaccines, adjuvants and negative co-stimulatory blockade.
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Authors | Marko Lens |
Journal | Expert opinion on biological therapy
(Expert Opin Biol Ther)
Vol. 8
Issue 3
Pg. 315-23
(Mar 2008)
ISSN: 1744-7682 [Electronic] England |
PMID | 18294102
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
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Topics |
- Animals
- Cancer Vaccines
(administration & dosage, immunology, therapeutic use)
- Humans
- Immunotherapy, Active
(methods, trends)
- Melanoma
(immunology, prevention & control)
- Skin Neoplasms
(immunology, prevention & control)
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