GAD1 single nucleotide polymorphism is in linkage disequilibrium with a child bipolar I disorder phenotype.

Abstract

BACKGROUND:

Pediatric bipolar I disorder (BP-I) and childhood schizophrenia (SZ) share certain symptoms (e.g., psychosis, aggression/irritability [A/I]), and the psychotic and A/I features are treated with neuroleptics in both disorders. Thus, it is of interest to examine the association of GAD1 to child BP-I because of its recently reported association to childhood SZ.

METHODS:

Child BP-I probands were obtained by consecutive new case ascertainment, and the phenotype was defined as current DSM-IV BP-I (manic or mixed phase) with at least one of the cardinal symptoms of mania (i.e., elation and/or grandiosity) and a Children's Global Assessment Scale score < or =60 (clinical impairment). These child BP-I probands are part of a large, ongoing, longitudinal study in which the phenotype has been validated by unique symptoms, longitudinal stability, and 7-8 times greater family loading than adult BP-I probands. Genotyping was performed using a TaqMan Validated SNP Genotyping Assay, and FBAT was used for analysis.

RESULTS:

There were 48 families. The rs2241165 A allele was preferentially transmitted (FBAT chi(2) = 5.2, df = 1, p = 0.022). No interaction between this GAD1 SNP and the Val66 BDNF allele was found.

CONCLUSIONS:

These data are consistent with some shared genetic vulnerability between child BP-I and SZ, which may be related to similar treatments.

• Authors: Barbara Geller, Rebecca Tillman, Kristine Bolhofner, Kathleen Hennessy, Edwin H Cook Jr
• Journal: Journal of child and adolescent psychopharmacology (J Child Adolesc Psychopharmacol) Vol. 18 Issue 1 Pg. 25-9 (Feb 2008) ISSN: 1044-5463 [Print] United States
• PMID: 18294085 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Glutamate Decarboxylase
• glutamate decarboxylase 1

Topics

• Adolescent
• Bipolar Disorder (genetics)
• Child
• Glutamate Decarboxylase (genetics)
• Humans
• Linkage Disequilibrium
• Phenotype
• Polymorphism, Single Nucleotide