Abstract | BACKGROUND: METHODS: Four groups of male Sprague-Dawley rats were surgically prepared and subjected to 90 min of CPB. Group A was normothermic (37.5 degrees C) during and after CPB. Group B underwent hypothermic (32 degrees C) CPB, followed by rewarming to 37.5 degrees C at the end of bypass. Group C had hypothermic (32 degrees C) CPB, followed by limited rewarming to 35 degrees C. Group D had normothermic CPB with hypothermia (35 degrees C) induced only postoperatively. Groups were compared for POCD determined by the performance in the Morris water maze on postoperative days 3-9. Histologic analysis of the brains (CA1 and CA3 hippocampal regions) was also performed. RESULTS:
Hypothermia induced only during (group B versus group A) or after CPB (group D versus group A) conferred no significant POCD benefit. Hypothermia when induced during CPB and continued into the postoperative period resulted in a significant improvement in water maze performance versus all other temperature regimens (group C versus group A, P = 0.044; group C versus group B, P = 0.011; group C versus group D, P = 0.012). No histological differences among groups were demonstrated. CONCLUSIONS: The combination of hypothermic (32 degrees C) CPB coupled with limited rewarming and prolonged postoperative hypothermia (35 degrees C) decreased POCD after CPB in rats.
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Authors | Fellery de Lange, Wilbert L Jones, George Burkhard Mackensen, Hilary P Grocott |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 106
Issue 3
Pg. 739-45, table of contents
(Mar 2008)
ISSN: 1526-7598 [Electronic] United States |
PMID | 18292411
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- Behavior, Animal
- Cardiopulmonary Bypass
(adverse effects)
- Cognition
- Cognition Disorders
(etiology, pathology, prevention & control, psychology)
- Hippocampus
(pathology)
- Hypothermia, Induced
- Male
- Maze Learning
- Models, Animal
- Postoperative Period
- Rats
- Rats, Sprague-Dawley
- Rewarming
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