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Queuine promotes antioxidant defence system by activating cellular antioxidant enzyme activities in cancer.

Abstract
Constant generation of Reactive oxygen species (ROS) during normal cellular metabolism of an organism is generally balanced by similar rate of consumption by antioxidants. Imbalance between ROS production and antioxidant defense results in increased level of ROS causing oxidative stress which leads to promotion of malignancy. Queuine is a hyper modified base analogue of guanine, found at first anti-codon position of Q- family of tRNAs. These tRNAs are completely modified with respect to queuosine in terminally differentiated somatic cells, however hypomodification of Q-tRNAs is close association with cell proliferation. Q-tRNA modification is essential for normal development, differentiation and cellular functions. Queuine is a nutrient factor to eukaryotes. It is found to promote cellular antioxidant defense system and inhibit tumorigenesis. The activities of antioxidant enzymes like catalase, SOD, glutathione peroxidase and glutathione reductase are found to be low in Dalton's lymphoma ascites transplanted (DLAT) mouse liver compared to normal. However, exogenous administration of queuine to DLAT mouse improves the activities of antioxidant enzymes. The results suggest that queuine promotes antioxidant defense system by increasing antioxidant enzyme activities and in turn inhibits oxidative stress and tumorigenesis.
AuthorsChandramani Pathak, Yogesh K Jaiswal, Manjula Vinayak
JournalBioscience reports (Biosci Rep) Vol. 28 Issue 2 Pg. 73-81 (Apr 2008) ISSN: 0144-8463 [Print] England
PMID18290765 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticodon
  • Antioxidants
  • Reactive Oxygen Species
  • Guanine
  • queuine
Topics
  • Animals
  • Anticodon (chemistry)
  • Antioxidants (metabolism)
  • Gene Expression Regulation
  • Guanine (analogs & derivatives, chemistry)
  • Liver (metabolism)
  • Lymphocytes (metabolism)
  • Male
  • Mice
  • Neoplasm Transplantation
  • Neoplasms (metabolism)
  • Oxidative Stress
  • Reactive Oxygen Species
  • Time Factors

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