Abstract |
TNF-alpha is a pleiotropic cytokine that is considered as a primary modifier of inflammatory and immune reaction in response to various inflammatory diseases and tumour. We investigated levels of TNF-alpha in 43 radicular cysts and 15 odontogenic keratocysts, obtained from patients undergoing surgery, under local anaesthesia, and after aspiration of cystic fluid from non-ruptured cysts. TNF-alpha is elevated in both cysts' fluid, but higher values were found in radicular cysts in comparison to keratocysts. The significantly higher concentration of TNF-alpha was associated with smaller radicular cysts, higher protein concentration, higher presence of inflammatory cells in peri cystic tissues, and the degree of vascularisation and cysts wall thickness (Mann-Whitney U-test, p < 0.05). No correlation was found based on these parameters in odontogenic keratocyst, but all cysts have detectable concentrations of TNF-alpha. We here for the first time present that a difference in the concentration of TNF-alpha exists between these two cystic types.
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Authors | Vladimir Jurisic, Snjezana Colic, Milan Jurisic |
Journal | Acta medica (Hradec Kralove)
(Acta Medica (Hradec Kralove))
Vol. 50
Issue 4
Pg. 233-8
( 2007)
ISSN: 1211-4286 [Print] Czech Republic |
PMID | 18290546
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Tumor Necrosis Factor-alpha
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Topics |
- Cyst Fluid
(chemistry)
- Humans
- Odontogenic Cysts
(chemistry)
- Radicular Cyst
(chemistry)
- Tumor Necrosis Factor-alpha
(analysis)
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