[Inhibition by dehydroepiandrosterone of aggression responses of spayed female mice towards lactating intruders is potentiated by neonatal androgenization].

Abstract

Female mice of an inbred Swiss strain were injected subcutaneously (s.c.) with either testosterone propionate or oil-vehicle on the day of birth. Once adult (8 week-old), they were spayed, and then treated either with dehydroepiandrosterone (80 micrograms/day s.c. for 15 days) or with solvent. The decrease of biting attacks by dehydroepiandrosterone was definitely more prominent in neonatally imprinted females than in controls.

• Authors: M Haug, J Young, P Robel, E E Baulieu
• Journal: Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie (C R Acad Sci III) Vol. 312 Issue 10 Pg. 511-6 ( 1991) ISSN: 0764-4469 [Print] France
• Vernacular Title: L'inhibition par le déhydroépiandrostérone des réponses agressives de souris femelles castrées vis-à-vis d'intruses allaitantes est potentialisée par l'androgénisation néonatale.
• PMID: 1829018 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Testosterone
• Dehydroepiandrosterone

Topics

• Animals
• Dehydroepiandrosterone (pharmacology, therapeutic use)
• Drug Synergism
• Female
• Lactation (psychology)
• Mice
• Ovariectomy (psychology)
• Pregnancy
• Stress, Physiological (drug therapy)
• Testosterone (pharmacology)