Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia.

Abstract

AIMS:

Although the expression of oligodendrocyte-related genes in post-mortem brains of patients with schizophrenia is consistently reported to be downregulated, the cause of the change remains unclear. The A-allele of rs2070106 within the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an oligodendrocyte-related gene, was reported to show reduced expression compared with the G-allele, and proposed to be associated with schizophrenia.

METHODS:

The effect of the rs2070106 genotype on the expression of CNP and other oligodendrocyte-related genes was examined using data previously obtained from DNA microarray studies of post-mortem brains.

RESULTS:

It was found that the effect of rs2070106 genotype on the CNP expression was transcript specific, and that the genotype was not associated with the expression of other oligodendrocyte-related genes.

CONCLUSIONS:

The rs207016 genotype is not likely to contribute to the reported coordinated down-regulation of oligodendrococyte-related genes in schizophrenia.

• Authors: Kazuya Iwamoto, Junko Ueda, Miki Bundo, Yoko Nakano, Tadafumi Kato
• Journal: Psychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 62 Issue 1 Pg. 103-8 (Feb 2008) ISSN: 1440-1819 [Electronic] Australia
• PMID: 18289148 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Myelin Proteins
• 2',3'-Cyclic-Nucleotide Phosphodiesterases

Topics

• 2',3'-Cyclic-Nucleotide Phosphodiesterases (genetics)
• Bipolar Disorder (diagnosis, genetics, pathology)
• Depressive Disorder, Major (diagnosis, genetics, pathology)
• Down-Regulation (genetics)
• Gene Expression (genetics)
• Gene Expression Profiling
• Genotype
• Humans
• Myelin Proteins (genetics)
• Oligodendroglia (metabolism, pathology)
• Oligonucleotide Array Sequence Analysis
• Polymorphism, Single Nucleotide (genetics)
• Prefrontal Cortex (pathology)
• Schizophrenia (diagnosis, genetics, pathology)