Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients.

Abstract

The serotonin 5-HT(2A) receptor is suspected to be involved in a number of psychiatric disorders, including schizophrenia. In particular, atypical antipsychotics have antagonistic effects on the 5-HT(2A) receptors, supporting a specific role of the 5-HT(2A) receptor in the pathophysiology of this disease. The aim of this study is to investigate cortical and subcortical 5-HT(2A) binding in neuroleptic-naive schizophrenic patients. Fifteen neuroleptic-naive patients diagnosed with schizophrenia (age 27.5+/-4.5 years), 11 men and 4 women, and 15 healthy control subjects matched for age (28.5+/-5.7 years) and gender underwent a 40 min positron emission tomography (PET) study using the 5-HT(2A) antagonist, [(18)F]altanserin, as a radioligand. PET images were co-registered to 3 T magnetic resonance images (MRIs) for each individual subject, and ROIs were applied automatically onto the individual MRIs and PET images. The cerebellum was used as a reference region. The binding potential of specific tracer binding (BP(p)) was used as the outcome measure. No significant difference was seen in cortical receptor distribution between patients and controls. An increase in 5-HT(2A) receptor binding in the caudate nucleus was detected in the group of schizophrenic patients (0.7+/-0.1) when compared to the healthy controls (0.5+/-0.3) (p=0.02). Our results confirm other in vivo findings of no difference in cortical 5-HT(2A) receptor binding between first-episode antipsychotic-naive schizophrenic patients and age- and gender-matched healthy control subjects. However, a preliminary finding of increased 5-HT(2A) binding in the caudate nucleus requires further investigation to explore the relation of subcortical and cortical 5-HT(2A) receptor binding.

• Authors: David Erritzoe, Hans Rasmussen, Klaus T Kristiansen, Vibe G Frokjaer, Steven Haugbol, Lars Pinborg, William Baaré, Claus Svarer, Jacob Madsen, Henrik Lublin, Gitte M Knudsen, Birte Y Glenthoj
• Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Neuropsychopharmacology) Vol. 33 Issue 10 Pg. 2435-41 (Sep 2008) ISSN: 1740-634X [Electronic] England
• PMID: 18288096 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents
• Receptor, Serotonin, 5-HT2A
• Serotonin Antagonists
• Serotonin
• altanserin
• Ketanserin

Topics

• Adult
• Antipsychotic Agents (pharmacology)
• Binding, Competitive (drug effects, physiology)
• Brain (diagnostic imaging, drug effects, metabolism)
• Brain Chemistry (drug effects, physiology)
• Brain Mapping
• Caudate Nucleus (diagnostic imaging, drug effects, metabolism)
• Cerebral Cortex (diagnostic imaging, drug effects, metabolism)
• Female
• Humans
• Ketanserin (analogs & derivatives, metabolism)
• Magnetic Resonance Imaging
• Male
• Positron-Emission Tomography
• Receptor, Serotonin, 5-HT2A (drug effects, metabolism)
• Schizophrenia (diagnostic imaging, drug therapy, metabolism)
• Serotonin (metabolism)
• Serotonin Antagonists (metabolism)
• Young Adult