Is NAN-190 an effective antagonist of the hypothermia and hyperglycemia induced by the 5-HT1A receptor agonist, 8-OH-DPAT?

Abstract

The putative 5-HT1A receptor antagonist properties of 1-(2-methoxyphenyl)-4-[4-(2-phtalimmido)butyl] piperazine (NAN-190) were studied in mice. The responses studied were hypothermia- and hyperglycemia-induced by the 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). NAN-190 (0.3-3 mg/kg) did not antagonize either response, but rather appeared to be additive with the effect produced by 8-OH-DPAT (0.25 mg/kg) alone, at least with respect to temperature. NAN-190, given alone in similar doses, caused hypothermia and hyperglycemia. These results suggest that NAN-190 has similar properties to 8-OH-DPAT with regard to temperature and glucose effects. Therefore, it does not appear to be a effective antagonist for all 5-HT1A-mediated responses.

• Authors: K M Wozniak, M J Durcan, M Linnoila
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 193 Issue 2 Pg. 253-6 (Feb 07 1991) ISSN: 0014-2999 [Print] Netherlands
• PMID: 1828770 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Piperazines
• Serotonin Antagonists
• Tetrahydronaphthalenes
• 1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine
• 8-Hydroxy-2-(di-n-propylamino)tetralin

Topics

• 8-Hydroxy-2-(di-n-propylamino)tetralin
• Animals
• Hyperglycemia (chemically induced, prevention & control)
• Hypothermia, Induced
• Male
• Mice
• Piperazines (administration & dosage, pharmacology)
• Premedication
• Serotonin Antagonists (pharmacology)
• Tetrahydronaphthalenes (administration & dosage, pharmacology)