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Age and dietary form of vitamin K affect menaquinone-4 concentrations in male Fischer 344 rats.

Abstract
Phylloquinone, the primary dietary form of vitamin K, is converted to menaquinone-4 (MK-4) in certain tissues. MK-4 may have tissue-specific roles independent of those traditionally identified with vitamin K. Fischer 344 male rats of different ages (2, 12, and 24 mo, n = 20 per age group) were used to compare the conversion of phylloquinone to MK-4 with an equivalent dose of another dietary form of vitamin K, 2',3'-dihydrophylloquinone. Rats were age- and diet-group pair-fed phylloquinone (198 +/- 9.0 microg/kg diet) or dihydrophylloquinone (172 +/- 13.0 microg/kg diet) for 28 d. MK-4 was the primary form of vitamin K in serum, spleen, kidney, testes, bone marrow, and brain myelin fractions, regardless of age group. MK-4 concentrations were significantly lower in kidney, heart, testes, cortex (myelin), and striatum (myelin) in the dihydrophylloquinone diet group compared with the phylloquinone diet group (P < 0.05). The MK-4 concentrations in 2-mo-old rats were lower in liver, spleen, kidney, heart, and cortex (myelin) but higher in testes compared with 24-mo-old rats (P < 0.05). However, there were no age-specific differences in MK-4 concentrations among the rats fed the 2 diets. These data suggest that dihydrophylloquinone, which differs from phylloquinone in its side phytyl chain, is absorbed but its intake results in less MK-4 in certain tissues. Dihydrophylloquinone may be used in models for the study of tissue-specific vitamin K deficiency.
AuthorsSarah L Booth, James W Peterson, Donald Smith, M Kyla Shea, John Chamberland, Natalia Crivello
JournalThe Journal of nutrition (J Nutr) Vol. 138 Issue 3 Pg. 492-6 (Mar 2008) ISSN: 1541-6100 [Electronic] United States
PMID18287355 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Vitamin K 2
  • Vitamin K
  • menatetrenone
Topics
  • Aging (physiology)
  • Animals
  • Bone Marrow (chemistry)
  • Brain Chemistry
  • Diet
  • Dose-Response Relationship, Drug
  • Kidney (chemistry)
  • Liver (chemistry)
  • Male
  • Myocardium (chemistry)
  • Rats
  • Rats, Inbred F344
  • Spleen (chemistry)
  • Testis (chemistry)
  • Vitamin K (administration & dosage, chemistry, pharmacology)
  • Vitamin K 2 (analogs & derivatives, analysis, blood, metabolism)

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