Circulating surfactant protein A (SP-A), a marker of lung injury, is associated with insulin resistance.

Abstract

OBJECTIVES:

Impaired lung function and inflammation have both attracted interest as potentially novel risk factors for glucose intolerance, insulin resistance, and type 2 diabetes. We hypothesized that circulating levels of surfactant protein (SP)-A, which reflects interstitial lung injury, could be associated with altered glucose tolerance and insulin resistance.

RESEARCH DESIGN AND METHODS:

Circulating SP-A concentration and metabolic variables (including insulin sensitivity by minimal model method, n = 89) were measured in 164 nonsmoking men.

RESULTS:

Circulating SP-A concentration was significantly higher among patients with glucose intolerance and type 2 diabetes than in subjects with normal glucose tolerance, even after adjustment for BMI, age, and smoking status (ex/never). The most significant differences were found in overweight and obese subjects with altered glucose tolerance (n = 59) who showed significantly increased serum SP-A concentrations (by a mean of 24%) compared with obese subjects with normal glucose tolerance (n = 58) (log SP-A 1.54 +/- 0.13 vs. 1.44 +/- 0.13; P < 0.0001). Insulin sensitivity (P = 0.003) contributed independently to 22% of SP-A variance among all subjects. In subjects with altered glucose tolerance, insulin sensitivity (P = 0.01) and fasting triglycerides (P = 0.02) contributed to 37% of SP-A variance. Controlling for serum creatinine or C-reactive protein in these models did not significantly change the results.

CONCLUSIONS:

Lung-derived SP-A protein was associated with altered glucose tolerance and insulin resistance in 164 nonsmoking men.

• Authors: José Manuel Fernández-Real, Berta Chico, Masanori Shiratori, Yusuke Nara, Hiroki Takahashi, Wifredo Ricart
• Journal: Diabetes care (Diabetes Care) Vol. 31 Issue 5 Pg. 958-63 (May 2008) ISSN: 1935-5548 [Electronic] United States
• PMID: 18285549 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Blood Glucose
• Pulmonary Surfactant-Associated Protein A
• Cholesterol

Topics

• Biomarkers (blood)
• Blood Glucose (metabolism)
• Cholesterol (blood)
• Diabetes Mellitus, Type 2 (blood)
• Glucose Intolerance (blood)
• Humans
• Insulin Resistance
• Lung (physiopathology)
• Male
• Pulmonary Surfactant-Associated Protein A (blood)
• Reference Values
• Respiratory Distress Syndrome (blood)
• White People