HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Powerful bactericidal and sterilizing activity of a regimen containing PA-824, moxifloxacin, and pyrazinamide in a murine model of tuberculosis.

Abstract
PA-824 is a nitroimidazo-oxazine in clinical testing for the treatment of tuberculosis. We report that the novel combination of PA-824, moxifloxacin, and pyrazinamide cured mice more rapidly than the first-line regimen of rifampin, isoniazid, and pyrazinamide. If applicable to humans, regimens containing this combination may radically shorten the treatment of multidrug-resistant tuberculosis.
AuthorsEric Nuermberger, Sandeep Tyagi, Rokeya Tasneen, Kathy N Williams, Deepak Almeida, Ian Rosenthal, Jacques H Grosset
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 52 Issue 4 Pg. 1522-4 (Apr 2008) ISSN: 0066-4804 [Print] United States
PMID18285479 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Antitubercular Agents
  • Aza Compounds
  • Fluoroquinolones
  • Nitroimidazoles
  • Quinolines
  • pretomanid
  • Pyrazinamide
  • Moxifloxacin
Topics
  • Animals
  • Antitubercular Agents (administration & dosage, therapeutic use)
  • Aza Compounds (administration & dosage, therapeutic use)
  • Colony Count, Microbial
  • Disease Models, Animal
  • Drug Therapy, Combination
  • Female
  • Fluoroquinolones
  • Humans
  • Lung (microbiology)
  • Mice
  • Mice, Inbred BALB C
  • Moxifloxacin
  • Mycobacterium tuberculosis (drug effects, isolation & purification)
  • Nitroimidazoles (administration & dosage, therapeutic use)
  • Pyrazinamide (administration & dosage, therapeutic use)
  • Quinolines (administration & dosage, therapeutic use)
  • Treatment Outcome
  • Tuberculosis, Pulmonary (drug therapy, microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: