Abstract | BACKGROUND: RESULTS: All peptides tested showed high antibody responses, were long-lasting, and demonstrated good memory response. Epitope mapping indicated that peptide mutation did not lead to epitope switching. Mutant peptides induced different inflammation responses as evidenced by cytokine profiles. Ig isotyping indicated that adjuvant-free vaccination with peptides drove an adequate Th2 response. All anti-sera from vaccinated mice cross-reacted with human Abeta in APP/PS1 transgenic mouse brain tissue. CONCLUSION: Our study demonstrated that an adjuvant-free vaccine with different Abeta peptides can be an effective and safe vaccination approach against AD. This study represents the first report of adjuvant-free vaccines utilizing Abeta peptides carrying diverse mutations in the T-cell epitope. These largely positive results provide encouragement for the future of the development of human vaccinations for AD.
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Authors | Chuanhai Cao, Xiaoyang Lin, Monika M Wahi, Eugene A Jackson, Huntington Potter Jr |
Journal | BMC neuroscience
(BMC Neurosci)
Vol. 9
Pg. 25
(Feb 18 2008)
ISSN: 1471-2202 [Electronic] England |
PMID | 18282292
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Alzheimer Vaccines
- Amyloid beta-Peptides
- Cytokines
- Immunoglobulin G
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Topics |
- Alzheimer Vaccines
(administration & dosage, immunology)
- Amyloid beta-Peptides
(administration & dosage, genetics, immunology)
- Animals
- Cross Reactions
- Cytokines
(metabolism)
- Epitope Mapping
- Immunoglobulin G
(immunology)
- Immunologic Memory
- Mice
- Mice, Inbred BALB C
- Mutation
- T-Lymphocytes
(immunology)
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