Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns.

Abstract

The CAG repeat lengths weighted by X-inactivation ratios were significantly shorter in 58 Japanese patients with premature ovarian failure (POF) than in 42 age-matched control females with normal menses. The results suggest that short CAG repeats with a relatively high androgen receptor function may constitute a susceptibility factor for the development of POF.

• Authors: Fumihiro Sugawa, Yuka Wada, Tetsuo Maruyama, Hiroshi Uchida, Bunpei Ishizuka, Tsutomu Ogata
• Journal: Fertility and sterility (Fertil Steril) Vol. 91 Issue 2 Pg. 649-52 (Feb 2009) ISSN: 1556-5653 [Electronic] United States
• PMID: 18281036 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• AR protein, human
• Follicle Stimulating Hormone, Human
• Receptors, Androgen
• Estradiol
• Luteinizing Hormone

Topics

• Adult
• Asian People (genetics)
• Case-Control Studies
• Estradiol (blood)
• Female
• Follicle Stimulating Hormone, Human (blood)
• Gene Frequency
• Genetic Predisposition to Disease
• Humans
• Japan
• Luteinizing Hormone (blood)
• Middle Aged
• Phenotype
• Primary Ovarian Insufficiency (blood, genetics)
• Receptors, Androgen (genetics)
• Risk Factors
• Trinucleotide Repeats
• X Chromosome Inactivation
• Young Adult