Local dermal hypersensitivity from dobutamine hydrochloride (Dobutrex solution) injection.

Abstract	Two patients had local dermal hypersensitivity at the site of dobutamine hydrochloride (Dobutrex solution) injection. Such local dermal lesions characterized by erythema, pruritus, and phlebitis with or without bullae formation have not been reported previously (to our knowledge). Hypersensitivity reaction to sulfites as a possible mechanism of the dermal lesions was substantiated further by skin tests and peripheral eosinophila. Oral antihistamine therapy can minimize such a minor but bothersome problem.
Authors	C C Wu, W J Chen, J J Cheng, Y Y Hsieh, W P Lien
Journal	Chest (Chest) Vol. 99 Issue 6 Pg. 1547-8 (Jun 1991) ISSN: 0012-3692 [Print] United States
PMID	1828022 (Publication Type: Case Reports, Journal Article)
Chemical References	Dobutamine
Topics	Aged Aged, 80 and over Dobutamine (administration & dosage, adverse effects) Drug Eruptions (diagnosis, etiology, pathology) Humans Infusions, Intravenous Male Middle Aged Skin Diseases, Vesiculobullous (chemically induced) Skin Tests

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!