[Primary mediastinal large B-cell lymphoma:a report of 24 cases with literature review].

Abstract

BACKGROUND & OBJECTIVE:

Primary mediastinal large B-cell lymphoma (PMBCL) is an uncommon subtybe of diffuse large B-cell lymphoma (DLBCL). This study was to investigate optimal treatment and prognostic factors of PMBCL by analyzing its clinical features.

METHODS:

Clinical records of 24 PMBCL patients, treated in Fujian Provincial Tumor Hospital from 1995 to 2005, were reviewed.

RESULTS:

Of the 24 patients, 16 were men and 8 were women, aged from 12 to 81; 20 were at stage I-II, 1 at stage III, and 3 at stage IV; 13 had bulk disease; 10 had superior vena cava syndrome; 14 had contiguous infiltration; 15 had lacate dehydrogenase elevation; 11 received chemoradiotherapy, 10 received chemotherapy alone, and 3 received radiotherapy alone; 10 achieved complete remission (CR) after scheduled treatment, 12 achieved partial remission (PR), 1 had stable disease and 1 had progressive disease. The median survival time was 89 months; the 3-year overall survival rate was 69%. At the end of follow-up, the patients initially achieved CR were all alive. International prognostic index (IPI) did not predict survival in this analysis, while bulk disease predicted poor survival.

CONCLUSIONS:

PMBCL has a male dominance in this analysis. Its clinical presentation is critical. Prompt diagnosis is needed. Anthracycline-based chemotherapy with radiotherapy may lead to favorable outcome. The patients with bulk disease have poor survival.

• Authors: Dao-Guang Chen, Yu Yang, Cai-Zhu Pan
• Journal: Ai zheng = Aizheng = Chinese journal of cancer (Ai Zheng) Vol. 27 Issue 2 Pg. 187-90 (Feb 2008) China
• PMID: 18279619 (Publication Type: English Abstract, Journal Article, Review)

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Child
• Diagnosis, Differential
• Female
• Humans
• Lymphoma, Large B-Cell, Diffuse (diagnosis, mortality, therapy)
• Male
• Mediastinal Neoplasms (diagnosis, mortality, therapy)
• Middle Aged
• Prognosis