T-helper 1-related chemokines in the exacerbation of childhood asthma.

Abstract

BACKGROUND:

T-helper (Th) 2 cytokines are thought to mediate most of the allergic inflammatory responses associated with atopic asthma. But the Th1-related chemokine, interferon-inducible protein 10 (IP-10)/CXCL10, was the predominant chemokine measured during human allergic pulmonary late-phase reaction. The aim of the present study was to evaluate the role of Th1- and Th2- related chemokines in the pathogenesis of asthma exacerbation.

METHODS:

Plasma levels of the Th2-related C-C chemokine I-309 (CCL1), the Th1-related CXC chemokines IP-10, and the monokine induced by interferon-gamma (Mig)/CXCL9 were measured in patients with stable asthma.

RESULTS:

These results were compared to the results measured prior to, and after corticosteroid treatment, in patients who experienced asthma exacerbations. A significant increase in the plasma levels of IP-10 and Mig, but not I-309, were found in patients with an acute exacerbation in contrast to patients with stable asthma. Plasma levels of IP-10 and Mig were significantly higher in patients during an acute asthma exacerbation than during a subsequent convalescent period.

CONCLUSIONS:

The Th1-related CXC chemokines IP-10 and Mig may be useful inflammatory markers of asthma exacerbation in children.

• Authors: Shu-Tse Lai, Chih-Hsing Hung, Yi-Ming Hua, Shih-Hsien Hsu, Yuh-Jyh Jong, Jau-Ling Suen
• Journal: Pediatrics international : official journal of the Japan Pediatric Society (Pediatr Int) Vol. 50 Issue 1 Pg. 99-102 (Feb 2008) ISSN: 1328-8067 [Print] Australia
• PMID: 18279215 (Publication Type: Journal Article)

Chemical References

• CCL1 protein, human
• Chemokine CCL1
• Chemokine CXCL10
• Chemokine CXCL9

Topics

• Adolescent
• Asthma (physiopathology)
• Chemokine CCL1 (blood)
• Chemokine CXCL10 (blood)
• Chemokine CXCL9 (blood)
• Child
• Female
• Humans
• Male