Recommendation to include fragrance mix 2 and hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) in the European baseline patch test series.

Abstract

BACKGROUND:

The currently used fragrance mix in the European baseline patch test series (baseline series) fails to detect a substantial number of clinically relevant fragrance allergies.

OBJECTIVE:

To investigate whether it is justified to include hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) and fragrance mix 2 containing hydroxyisohexyl 3-cyclohexene carboxaldehyde, citral, farnesol, coumarin, citronellol, and alpha-hexyl cinnamal in the European baseline patch test series.

METHODS:

Survey of the literature on reported frequencies of contact allergy and allergic contact dermatitis from fragrance mix 2 and hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) as well as reported results of experimental provocation test.

RESULTS:

Fragrance mix 2 has been demonstrated to be a useful additional marker of fragrance allergy with contact allergy rates up to 5% when included in various national baseline patch test series. Of the fragrance substances present in fragrance mix 2, hydroxyisohexyl 3-cyclohexene carboxaldehyde is the most common sensitizer. Contact allergy rates between 1.5% and 3% have been reported for hydroxyisohexyl 3-cyclohexene carboxaldehyde in petrolatum (pet.) at 5% from various European centres when tested in consecutive dermatitis patients.

CONCLUSIONS:

From 2008, pet. preparations of fragrance mix 2 at 14% w/w (5.6 mg/cm(2)) and hydroxyisohexyl 3-cyclohexene carboxaldehyde at 5% w/w (2.0 mg/cm(2)) are recommended for inclusion in the baseline series. With the Finn Chamber technique, a dose of 20 mg pet. preparation is recommended. Whenever there is a positive reaction to fragrance mix 2, additional patch testing with the 6 ingredients, 5 if there are simultaneous positive reactions to hydroxyisohexyl 3-cyclohexene carboxaldehyde and fragrance mix 2, is recommended.

• Authors: Magnus Bruze, Klaus Ejner Andersen, An Goossens, ESCD, EECDRG
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 58 Issue 3 Pg. 129-33 (Mar 2008) ISSN: 1600-0536 [Electronic] England
• PMID: 18279149 (Publication Type: Journal Article, Review)

Chemical References

• Aldehydes
• Allergens
• Cyclohexenes
• Perfume
• hydroxyisohexyl 3-cyclohexene carboxaldehyde

Topics

• Aldehydes (adverse effects)
• Allergens (adverse effects)
• Cyclohexenes (adverse effects)
• Dermatitis, Allergic Contact (diagnosis, epidemiology, etiology, pathology)
• Europe (epidemiology)
• Humans
• Patch Tests (standards)
• Perfume (adverse effects)