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Immunoproliferative small intestinal disease with protein loss complicated with duodenal T cell lymphoma during progression.

Abstract
A 52-year-old man was admitted to our hospital in October 2001 with abdominal pain. Abdominal X-ray indicated a diagnosis of ileus. Histopathological and immunological examination resulted in a diagnosis of immunoproliferative small intestinal disease (IPSID). He was treated with THP-COP therapy (pirarubicin, cyclophosphamide, vincristine, and prednisolone), which resulted in complete remission. Outpatient follow-up revealed hypoalbuminemia in May 2003 and upper gastrointestinal endoscopy showed duodenal mucosal nodularity. He was diagnosed with relapsed IPSID and salvage chemotherapy was started. Follow-up endoscopy confirmed that the therapy was effective, but uncovered another duodenal mucosal nodularity. Immunohistochemical staining revealed T-cell lymphoma. Chemotherapy was discontinued and the patient died in December 2004.
AuthorsTakeshi Hara, Hisashi Tsurumi, Tomohiro Kato, Yasuyuki Imao, Yasushi Kojima, Keishi Kojima, Jun-ichi Kitagawa, Naoki Katsumura, Hiroshi Araki, Tsuyoshi Takami, Hisataka Moriwaki
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 47 Issue 4 Pg. 299-303 ( 2008) ISSN: 1349-7235 [Electronic] Japan
PMID18277034 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Proteins
Topics
  • Disease Progression
  • Duodenal Neoplasms (etiology)
  • Fatal Outcome
  • Humans
  • Immunoproliferative Small Intestinal Disease (complications, metabolism)
  • Lymphoma, T-Cell (etiology)
  • Male
  • Middle Aged
  • Proteins (metabolism)

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