| Abstract | A case of steroid-resistant adult-onset Still's disease is herein reported. The patient consulted us because of night fever, arthralgia and evanescent rashes. She was diagnosed with adult-onset Still's disease, with a C-reactive protein (CRP) value of 29.5 mg/dL and serum ferritin level of 4500 ng/mL. The fever, rashes and arthralgia disappeared after medication of medium-dose oral prednisolone, however, the CRP value persisted at high levels, and the serum ferritin level nevertheless increased by 5200 ng/mL. Following the pulse therapy with corticosteroid, the CRP value decreased once but thereafter returned to a high level again. The serum ferritin level did not respond during that therapy. Finally, 10 days after starting the administration of methotrexate, the CRP value dramatically decreased from 7 mg/dL to 0.16 mg/dL, and thereafter the serum ferritin level started to decline, which thus enabled us to eventually taper the dose of oral prednisolone. |
| Authors | Osamu Okamoto, Masaki Oishi, Sakuhei Fujiwara
(Affiliation: Dermatology, Department of Anatomy, Biology and Medicine, Faculty of Medicine, Oita University, Oita, Japan. ookamoto at med.oita-u.ac.jp)
|
| Journal | The Journal of dermatology
(J Dermatol)
Vol. 35
Issue 2
Pg. 106-10
(Feb 2008)
ISSN: 0385-2407 Japan |
| PMID | 18271807
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Antirheumatic Agents
- Glucocorticoids
- Methotrexate
|
| Topics |
- Antirheumatic Agents
(therapeutic use)
- Drug Resistance
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Methotrexate
(therapeutic use)
- Middle Aged
- Still's Disease, Adult-Onset
(drug therapy)
|
