Abnormally high level of C4b binding protein and deficiency of free fraction of protein S in a patient with systemic lupus erythematosus and recurrent thromboses.

Abstract	A patient with systemic lupus erythematosus and numerous thrombotic accidents was found to have a deficiency of the free fraction of protein S, most likely due to an abnormally high level of C4b binding protein. These abnormalities, unique in comparison to 4 other patients with hypercoagulation states, were partially corrected with cyclophosphamide. There was no evidence of a consumption of complement components. The interactions between the hemostasis system and the complement cascade are discussed.
Authors	A J Stankiewicz, M Steiner, E V Lally, S R Kaplan
Journal	The Journal of rheumatology (J Rheumatol) Vol. 18 Issue 1 Pg. 82-7 (Jan 1991) ISSN: 0315-162X [Print] Canada
PMID	1827159 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Blood Proteins Carrier Proteins Complement Inactivator Proteins Glycoproteins Protein S Complement C4b Cyclophosphamide
Topics	Adult Blood Proteins (deficiency) Carrier Proteins (analysis) Complement C4b (metabolism) Complement Inactivator Proteins Cyclophosphamide (therapeutic use) Female Glycoproteins (deficiency) Humans Immunoelectrophoresis, Two-Dimensional Lupus Erythematosus, Systemic (blood, complications) Protein S Recurrence Thrombosis (blood, complications)

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