[Early feeding in infancy and atopic dermatitis - a prospective observational study].

Abstract

BACKGROUND:

Recommendations for primary prevention of allergic diseases in high-risk children include hypoallergenic infant formulas (HA) if breastfeeding is insufficient. The primary objective of our study was to investigate the atopic dermatitis (AD) preventive effect of breastfeeding and HA-nutrition in the first 2 years of life and to follow the increase in weight.

PATIENTS AND METHODS:

Altogether 174 newborns with a hereditary risk for atopy were enrolled in the study, 121 children were investigated at the age of 2 months, 111 at the age of 4 and 106 at the age of 6 months. A total of 45 infants were in the first half-year of life exclusively breastfed and 61 infants were mainly fed with HA.

RESULTS:

The body weight of initially HA-fed children was 7870G (SD 949) significantly higher as the one of breastfed children (7508 G, SD 912, p=0.0571), in addition the weight increase was also significantly higher in HA-fed infants at the age of 6 months (p=0.0042). The frequency of AD as well as SCORAD score at the age of 6 to 24 months was comparable in both groups. Neither the milk-specific IgE antibodies nor the proliferation of peripheral blood mononuclear cells (PBMC) to bovine beta-Lactoglobulin (BLG) at the age of 6 months had a prognostic value for development of atopic dermatitis.

CONCLUSION:

The likelihood to develop AD in the first 2 years of life was comparable in exclusively breastfed as in HA-fed infants with hereditary risk for atopy. The initially HA-fed children demonstrated at the age of 6 months higher body weight and weight increase as the exclusively breastfed infants. The efficacy of nutritional intervention on the incidence of AD in high-risk children for atopy could not be predicted by milk-specific IgE antibodies or BLG-specific proliferation of PBMC.

• Authors: I Nentwich, A Pazdírková, J Lokaj, Z Szepfalusi, H Hrstková
• Journal: Klinische Padiatrie (Klin Padiatr) 2009 Mar-Apr Vol. 221 Issue 2 Pg. 78-82 ISSN: 0300-8630 [Print] Germany
• Vernacular Title: Säuglingsernährung und atopische Dermatitis - eine prospektive Beobachtungsstudie.
• PMID: 18270883 (Publication Type: English Abstract, Journal Article)

Chemical References

• Milk Proteins
• Protein Hydrolysates
• Immunoglobulin E

Topics

• Body Weight
• Breast Feeding
• Dermatitis, Atopic (genetics, immunology, prevention & control)
• Female
• Follow-Up Studies
• Genetic Predisposition to Disease (genetics)
• Humans
• Immunoglobulin E (blood)
• Infant
• Infant Formula
• Infant, Newborn
• Male
• Milk Hypersensitivity (genetics, immunology, prevention & control)
• Milk Proteins (immunology)
• Neutrophils (immunology)
• Prospective Studies
• Protein Hydrolysates
• Risk Factors