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Exacerbation of granular corneal dystrophy type II (Avellino corneal dystrophy) after LASEK.

AbstractPURPOSE:
To report cases of granular corneal dystrophy type II (Avellino corneal dystrophy) that were exacerbated by uncomplicated laser epithelial keratomileusis (LASEK) for myopia.
METHODS:
Eight patients (15 eyes) with granular corneal dystrophy type II who underwent LASEK were examined by DNA sequencing, slit-lamp microscopy, and confocal microscopy.
RESULTS:
The number and density of the opacities increased after LASEK. Best spectacle-corrected visual acuity decreased after LASEK as the density of the opacities increased. In three patients, mitomycin C was used intraoperatively, but corneal deposits also worsened in these patients.
CONCLUSIONS:
LASEK is contraindicated in patients with granular corneal dystrophy type II because vision may be reduced from an increase in the density of corneal opacities postoperatively.
AuthorsJae Hwan Lee, R Doyle Stulting, Dong Ho Lee, Christopher Seungkyu Lee, Woon Cho Kim, Eung Kweon Kim
JournalJournal of refractive surgery (Thorofare, N.J. : 1995) (J Refract Surg) Vol. 24 Issue 1 Pg. 39-45 (01 2008) ISSN: 1081-597X [Print] United States
PMID18269147 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adult
  • Contraindications
  • Cornea (physiopathology)
  • Corneal Dystrophies, Hereditary (etiology, physiopathology)
  • Female
  • Humans
  • Keratectomy, Subepithelial, Laser-Assisted (adverse effects)
  • Lasers, Excimer
  • Male
  • Microscopy, Confocal
  • Myopia (physiopathology, surgery)
  • Sequence Analysis, DNA
  • Visual Acuity

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