Abstract | BACKGROUND AND AIM: METHODS: The plasma 5-HT/5-HIAA concentrations at 0, 30 min, 60 min, 90 min, 120 min, 150 min and 180 min following cold or warm water intake were investigated in 32 female subjects with d-IBS and 21 healthy female subjects. Gastric mucosal 5-HT under fasting conditions and following water intake were further investigated in 15 d-IBS patients and nine healthy subjects. Symptomatology was assessed throughout the study. RESULTS: The plasma 5-HT concentrations in IBS patients were significantly higher than those of controls at 30 min (P = 0.022), 60 min (P < 0.001), 90 min (P < 0.001), 120 min (P < 0.001) and 150 min (P = 0.001) after cold water intake. The peak plasma 5-HT/5-HIAA and area under the curve for 5-HT/5-HIAA were also higher in d-IBS patients (P < 0.001). Gastric mucosal 5-HT in d-IBS patients and controls did not show any significant differences both under fasting condition (P = 0.596) and after cold water intake (P = 0.426). Last, the d-IBS patients with symptoms had higher 5-HT concentration (P < 0.001) and there was a positive correlation (r = 0.714, P = 0.001)between the symptomatology and plasma 5-HT level. CONCLUSIONS: These data suggest that symptomatology following cold water intake may be associated with increased plasma 5-HT concentrations in female subjects with d-IBS.
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Authors | Xiu Li Zuo, Yan Qing Li, Xiao Zhong Yang, Min Guo, Yu Ting Guo, Xue Feng Lu, Jun Man Li, Paul V Desmond |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 22
Issue 12
Pg. 2330-7
(Dec 2007)
ISSN: 0815-9319 [Print] Australia |
PMID | 18265445
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Serotonin
- Hydroxyindoleacetic Acid
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Topics |
- Adult
- Area Under Curve
- Blood Platelets
- Cold Temperature
- Diarrhea
(blood, complications)
- Drinking
- Fasting
- Female
- Gastric Mucosa
(metabolism)
- Humans
- Hydroxyindoleacetic Acid
(blood)
- Irritable Bowel Syndrome
(blood, complications)
- Middle Aged
- Serotonin
(blood)
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