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[Metalloproteinase activity of the blood in patients with arterial hypertension with paroxysmal form of atrial fibrillation].

Abstract
Aim of the study was to investigate interrelationship between serum markers of myocardial fibrosis: matrix metalloproteinase -1 (MMP-1), tissue inhibitor of metalloproteinase-1 (TIMP-1) and parameters of echocardiography in patients with arterial hypertension (AH) and paroxysmal form of atrial fibrillation (n=39). We revealed positive correlation of levels of TIMP-1 with thickness of interventricular septum in diastole (r=0,47, p=0,02), peak velocity of late filling of the right ventricle (r=0,46, p=0,01), and negative relation between MMP-1 levels and degree of mitral and tricuspid regurgitation (r=0,43, p=0,005 and r=0,38, p=0,04, respectively). In the group of patients with increased left ventricular myocardial mass index (LVMMI) TIMP-1 level was significantly higher than in patients with normal LVMMI (p < 0,05). In the group combining patients with concentric and eccentric LV hypertrophy TIMP-1 level was significantly higher than in the group combining patients with LV concentric remodeling and normal geometry (p < 0,05). No correlations were revealed between MMP-1 and TIMP-1 levels and parameters of diastolic dysfunction. In patients with AH increase of serum concentrations of TIMP-1 was associated with increased thickness of interventricular septum, increase of LVMMI, and with prognostically unfavorable types of LV remodeling.
AuthorsF M Khezheva, N A Mazur, V P Masenko
JournalKardiologiia (Kardiologiia) Vol. 47 Issue 12 Pg. 10-4 ( 2007) ISSN: 0022-9040 [Print] Russia (Federation)
PMID18260972 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Biomarkers
  • Tissue Inhibitor of Metalloproteinase-1
  • Matrix Metalloproteinase 1
Topics
  • Adult
  • Aged
  • Atrial Fibrillation (complications, enzymology, physiopathology)
  • Biomarkers (blood)
  • Echocardiography, Doppler
  • Female
  • Follow-Up Studies
  • Heart Rate (physiology)
  • Heart Ventricles (diagnostic imaging, physiopathology)
  • Humans
  • Hypertension (complications, enzymology, physiopathology)
  • Male
  • Matrix Metalloproteinase 1 (blood)
  • Middle Aged
  • Myocardial Contraction
  • Tachycardia, Paroxysmal (complications, enzymology, physiopathology)
  • Tissue Inhibitor of Metalloproteinase-1 (blood)

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