Abstract |
Cerebrospinal fluid (CSF) and serum levels of 12 cytokines or chemokines important in central nervous system ( CNS) infections were measured in 76 Ugandan children with cerebral malaria (CM) and 8 control children. As compared with control children, children with cerebral malaria had higher cerebrospinal fluid levels of interleukin (IL)-6, CXCL-8/IL-8, granulocyte-colony stimulating factor ( G-CSF), tumor necrosis factor-alpha ( TNF-alpha), and IL-1 receptor antagonist. There was no correlation between cerebrospinal and serum cytokine levels for any cytokine except G-CSF. Elevated cerebrospinal fluid but not serum TNF-alpha levels on admission were associated with an increased risk of neurologic deficits 3 months later (odds ratio 1.55, 95% CI: 1.10, 2.18, P = 0.01) and correlated negatively with age-adjusted scores for attention (Spearman rho, -0.34, P = 0.04) and working memory (Spearman rho, -0.32, P = 0.06) 6 months later. In children with cerebral malaria, central nervous system TNF-alpha production is associated with subsequent neurologic and cognitive morbidity.
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Authors | Chandy C John, Angela Panoskaltsis-Mortari, Robert O Opoka, Gregory S Park, Paul J Orchard, Anne M Jurek, Richard Idro, Justus Byarugaba, Michael J Boivin |
Journal | The American journal of tropical medicine and hygiene
(Am J Trop Med Hyg)
Vol. 78
Issue 2
Pg. 198-205
(Feb 2008)
ISSN: 0002-9637 [Print] United States |
PMID | 18256412
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Case-Control Studies
- Child
- Child, Preschool
- Cognition Disorders
(etiology)
- Cytokines
(blood, cerebrospinal fluid)
- Humans
- Malaria, Cerebral
(cerebrospinal fluid, complications, immunology)
- Nervous System Diseases
(etiology)
- Prognosis
- Time Factors
- Uganda
(epidemiology)
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