[Dose-effect relationship of para-toluenesulfonamide for treatment of hepatocellular carcinoma in rats].

Abstract

OBJECTIVE:

To investigate the dose-effect relationship of para-toluenesulfonamide (PTS) for treatment of hepatocellular carcinoma in rats.

METHODS:

Forty-two SD rats bearing subcutaneous transplanted hepatocellular carcinoma were randomly divided into 6 groups (n=7), in which 0.02, 0.04, 0.06, 0.08, and 0.10 ml PTS and 0.10 ml normal saline were injected into the tumor, respectively. All of the rats were executed 24 h after the injection to observe the pathological changes in the tumor.

RESULTS:

In rats with saline injection, the tumor tissues exhibited no obvious changes and the tumor cells retained the active proliferation. PTS, in contrast, caused coagulation necrosis of the tumor tissue, and the necrotic area expanded with the increase of the injected doses. The necrotic volume of the tumor was in roughly linear correlation with the dose of PTS injected, with the linear regression equation of V (cm(3))=-0.018+2.595Y (where V represents tumor necrosis volume, and Y the injected dose of PTS).

CONCLUSION:

The dose-effect relationship of PTS is roughly linear, and the PTS dose for injection can be estimated according to the diameter of the tumor.

• Authors: Min-ying Li, Hui Meng, Wei-liang Zhu, Shao-zhang Zhou, Hong-yi Li, Ji-ren Zhang
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 28 Issue 2 Pg. 249-51 (Feb 2008) ISSN: 1673-4254 [Print] China
• PMID: 18250054 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Sulfonamides
• Toluene
• 4-toluenesulfonamide

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Carcinoma, Hepatocellular (drug therapy, pathology)
• Cell Proliferation
• Dose-Response Relationship, Drug
• Necrosis
• Rats
• Rats, Sprague-Dawley
• Sulfonamides (therapeutic use)
• Toluene (analogs & derivatives, therapeutic use)