Action of aromatase inhibitor for treatment of uterine leiomyoma in perimenopausal patients.

Abstract

OBJECTIVE:

To assess the effect of the aromatase inhibitor on patients with leiomyoma in the reproductive stage regarding reduction of uterine volume and control of symptoms.

DESIGN:

Clinical study.

SETTING:

Academic clinical practice.

PATIENT(S):

Twenty patients, over 35 years of age, with symptomatic uterine leiomyoma.

INTERVENTION(S):

Anastrozol, 1 mg/day for 12 weeks.

MAIN OUTCOME MEASURE(S):

Measurement of uterine volume, assessment of symptoms related to uterine leiomyoma, serum assay of follicle stimulating hormone (FSH), and estradiol.

RESULTS:

Average reduction of uterine volume of 9.32%, attaining up to 32%, and reduction of symptoms of uterine leiomyoma (menstrual volume, duration of menstruation, and dysmenorrhea). No significant change in serum levels of FSH and estradiol during use of the medication were observed.

CONCLUSION(S):

Anastrozol proved to be effective in reducing the volume of the uterus-leiomyoma structure, leading to the control of symptoms connected with the disorder without changes in serum FSH and estradiol.

• Authors: Sandro G Hilário, Nilo Bozzini, Rodrigo Borsari, Edmund C Baracat
• Journal: Fertility and sterility (Fertil Steril) Vol. 91 Issue 1 Pg. 240-3 (Jan 2009) ISSN: 1556-5653 [Electronic] United States
• PMID: 18249392 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Aromatase Inhibitors
• Nitriles
• Triazoles
• Anastrozole
• Estradiol
• Follicle Stimulating Hormone

Topics

• Adult
• Anastrozole
• Antineoplastic Agents, Hormonal (therapeutic use)
• Aromatase Inhibitors (therapeutic use)
• Estradiol (blood)
• Female
• Follicle Stimulating Hormone (blood)
• Humans
• Leiomyoma (drug therapy)
• Menstruation (drug effects, physiology)
• Middle Aged
• Nitriles (therapeutic use)
• Perimenopause
• Triazoles (therapeutic use)
• Uterine Neoplasms (blood, drug therapy)