| Abstract | The currently used pertussis vaccines are highly efficacious; however, neonates are susceptible to whooping cough up to the sixth month. In agreement, DTP-immunized neonate mice were not protected against intracerebral challenge with Bordetella pertussis. Neonate mice immunized with either DTP or a recombinant-BCG strain expressing the genetically detoxified S1 subunit of pertussis toxin do not show a humoral immune response against PT. On the other hand, rBCG-Pertussis induces higher PT-specific IFN-gamma production and an increase in both IFN-gamma(+) and TNF-alpha(+)-CD4(+)-T cells than the whole cell pertussis vaccine and confers protection against a lethal intracerebral challenge with B. pertussis. |
| Authors | Ivan P Nascimento, Waldely O Dias, Wagner Quintilio, Ana P Christ, Josefina F Moraes, Mary D C Vancetto, Gabriela Ribeiro-Dos-Santos, Isaias Raw, Luciana C C Leite
(Affiliation: Centro de Biotecnologia, Instituto Butantan, Av. Vital Brasil 1500, 05503-900 São Paulo, SP, Brazil.)
|
| Journal | Microbes and infection / Institut Pasteur
(Microbes Infect)
Vol. 10
Issue 2
Pg. 198-202
(Feb 2008)
ISSN: 1286-4579 France |
| PMID | 18248757
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antibodies, Bacterial
- Diphtheria-Tetanus-Pertussis Vaccine
- Pertussis Vaccine
- Tumor Necrosis Factor-alpha
- pertussis toxin, S1 subunit
- Interferon-gamma
- Pertussis Toxin
|
| Topics |
- Animals
- Antibodies, Bacterial
(blood)
- Bordetella pertussis
(genetics, immunology)
- CD4-Positive T-Lymphocytes
(immunology)
- Diphtheria-Tetanus-Pertussis Vaccine
(immunology)
- Humans
- Infant, Newborn
- Interferon-gamma
(biosynthesis)
- Mice
- Mycobacterium bovis
(genetics)
- Pertussis Toxin
(genetics, immunology)
- Pertussis Vaccine
(genetics, immunology)
- Survival Analysis
- Tumor Necrosis Factor-alpha
(biosynthesis)
- Whooping Cough
(immunology, prevention & control)
|
