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Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.

Abstract
The synthesis of several pyrrolidine inhibitor analogs is described that possess nanomolar in vitro potencies against the neuraminidase enzymes expressed by the B/Memphis/3/89 and A/N1/PR/8/34 influenza strains.
AuthorsA Chris Krueger, Yibo Xu, Warren M Kati, Dale J Kempf, Clarence J Maring, Keith F McDaniel, Akhteruzzaman Molla, Debra Montgomery, William E Kohlbrenner
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 18 Issue 5 Pg. 1692-5 (Mar 01 2008) ISSN: 1464-3405 [Electronic] England
PMID18242993 (Publication Type: Journal Article)
Chemical References
  • Antiviral Agents
  • Pyrrolidines
  • Neuraminidase
Topics
  • Antiviral Agents (chemistry, pharmacology)
  • Influenza A virus (drug effects)
  • Influenza B virus (drug effects)
  • Molecular Structure
  • Neuraminidase (antagonists & inhibitors)
  • Pyrrolidines (chemistry, pharmacology)
  • Structure-Activity Relationship

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