Abstract |
The synthesis of several pyrrolidine inhibitor analogs is described that possess nanomolar in vitro potencies against the neuraminidase enzymes expressed by the B/Memphis/3/89 and A/N1/PR/8/34 influenza strains.
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Authors | A Chris Krueger, Yibo Xu, Warren M Kati, Dale J Kempf, Clarence J Maring, Keith F McDaniel, Akhteruzzaman Molla, Debra Montgomery, William E Kohlbrenner |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 18
Issue 5
Pg. 1692-5
(Mar 01 2008)
ISSN: 1464-3405 [Electronic] England |
PMID | 18242993
(Publication Type: Journal Article)
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Chemical References |
- Antiviral Agents
- Pyrrolidines
- Neuraminidase
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Topics |
- Antiviral Agents
(chemistry, pharmacology)
- Influenza A virus
(drug effects)
- Influenza B virus
(drug effects)
- Molecular Structure
- Neuraminidase
(antagonists & inhibitors)
- Pyrrolidines
(chemistry, pharmacology)
- Structure-Activity Relationship
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