High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26:0) in whole blood are associated with metabolic syndrome in Japanese men.
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| Abstract | OBJECTIVE:
Hexacosanoic acid (C26:0) is a saturated very long-chain fatty acid and high levels of C26:0 in red blood cells are reported to be closely related with risk factors of atherosclerosis. However, the relationship between absolute levels of C26:0 in whole blood and metabolic syndrome (MS) has not been determined. MATERIALS AND METHOD: We divided 218 consecutive apparently healthy male subjects into an MS group (n=78) and a non-MS group (n=140) according to the definition of the International Diabetes Federation. The levels of C26:0 in whole blood were measured by gas liquid chromatography-mass spectrometry. RESULTS: The MS group had significantly higher levels of C26:0 than the non-MS group (2.42+/-0.31mug/ml vs. 2.25+/-0.29mug/ml, P=0001). There was a significant association between the levels of C26:0 and the number of factors of MS. The levels of C26:0 positively correlated with age, blood pressure, triglyceride and fasting plasma glucose. Multivariate analysis revealed that the level of C26:0 is still an independent variable for the presence of MS after adjustment for age and each criterion of MS. CONCLUSION: The absolute levels of C26:0 in whole blood appear to be associated with MS independent of its component parts.
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| Authors | Atsumi Kume, Tetsuro Miyazaki, Yohei Kitamura, Kyoichi Oshida, Naotake Yanagisawab, Hirotaka Takizawa, Kiyotaka Fujii, Takashi Kiyanagi, Katsuhiko Sumiyoshi, Hirotoshi Ohmura, Hiroshi Mokuno, Kazunori Shimada, Hiroyuki Daida |
| Journal | Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 80 Issue 2 Pg. 259-64 (May 2008) ISSN: 1872-8227 [Electronic] Ireland |
| PMID | 18242759 (Publication Type: Journal Article) |
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