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Induction of differentiation of myeloid leukemia cells in primary culture in response to lithocholic acid acetate, a bile acid derivative, and cooperative effects with another differentiation inducer, cotylenin A.

Abstract
Lithocholic acid (LCA) acetate induced the differentiation of human leukemia cells. Treatment with a combination of LCA acetate and cotylenin A, an inducer of the differentiation of leukemia cells, was more effective than that with LCA acetate or cotylenin A alone at inducing monocytic differentiation. LCA acetate activated mitogen-activated protein kinase (MAPK) before inducing differentiation. Cotylenin A did not activate MAPK, suggesting that cotylenin A has a different mode of action. The cooperative effects of LCA acetate and cotylenin A on inducing differentiation were, at least partly, due to the enhancement of LCA acetate-induced MAPK activation by cotylenin A.
AuthorsAkiyoshi Horie, Miho Akimoto, Hiroto Tsumura, Makoto Makishima, Takeshi Taketani, Seiji Yamaguchi, Yoshio Honma
JournalLeukemia research (Leuk Res) Vol. 32 Issue 7 Pg. 1112-23 (Jul 2008) ISSN: 0145-2126 [Print] England
PMID18242698 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA Primers
  • Diterpenes
  • cotylenin A
  • lithocholic acid acetate
  • Lithocholic Acid
  • Mitogen-Activated Protein Kinases
Topics
  • Base Sequence
  • Cell Differentiation (drug effects)
  • Cell Division (drug effects)
  • DNA Primers
  • Diterpenes (pharmacology)
  • HL-60 Cells
  • Humans
  • Lithocholic Acid (analogs & derivatives, pharmacology)
  • Mitogen-Activated Protein Kinases (metabolism)
  • Reverse Transcriptase Polymerase Chain Reaction

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