Abstract | BACKGROUND: OBJECTIVES: METHODS: RESULTS: We identified single Notch1-positive cells or small clusters of atypical cells in LyP. Similarly, strongly positive Jagged1 cells tended to be localized in clusters. Primary cutaneous ALCL had higher expression of Notch1 and Jagged1 compared with LyP. Cells expressing Notch1 and Jagged1 were colocalized and a subset of cells expressed both the receptor and the ligand. The expression of the ligand Delta1 was low to undetectable in both types of lymphoproliferations. A subpopulation of lymphoma cells was found to coexpress Notch1 and activated Akt kinase. CONCLUSIONS: These results imply a potential role for the Notch signalling pathway in the pathogenesis of primary cutaneous CD30+ lymphoproliferative disorders and provide a rationale for the exploration of the activity of Notch antagonists in the therapy of these diseases.
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Authors | M R Kamstrup, E Ralfkiaer, G L Skovgaard, R Gniadecki |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 158
Issue 4
Pg. 747-53
(Apr 2008)
ISSN: 0007-0963 [Print] England |
PMID | 18241263
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calcium-Binding Proteins
- Intercellular Signaling Peptides and Proteins
- JAG1 protein, human
- Jagged-1 Protein
- Ki-1 Antigen
- Ligands
- Membrane Proteins
- Receptor, Notch1
- Serrate-Jagged Proteins
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Calcium-Binding Proteins
(isolation & purification, metabolism)
- Female
- Humans
- Intercellular Signaling Peptides and Proteins
(isolation & purification, metabolism)
- Jagged-1 Protein
- Ki-1 Antigen
(isolation & purification, metabolism)
- Ligands
- Lymphoma, Large-Cell, Anaplastic
(immunology, pathology)
- Lymphomatoid Papulosis
(immunology, pathology)
- Male
- Membrane Proteins
(isolation & purification, metabolism)
- Middle Aged
- Receptor, Notch1
(isolation & purification, metabolism)
- Serrate-Jagged Proteins
- Signal Transduction
(immunology)
- Skin Neoplasms
(immunology, pathology)
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