Abstract | BACKGROUND: METHODS: We studied 46 patients (66+/-12 years; 75% men) who underwent direct current EC for persistent AF (mean duration: 30 weeks). Blood samples were drawn immediately prior to, and at one month post-EC. Baseline parameters were compared to 40 healthy subjects in sinus rhythm ('controls'). RESULTS: Patients with AF had increased levels of CRP (p=0.04) and lower levels of MMP-1 (p=0.002) compared with controls. EC was successful in 78%. There were no differences in baseline levels of CRP, MMP-1, TIMP-1 and ICTP between those where EC was unsuccessful, compared to those with immediate EC success. Patients who maintained sinus rhythm at 30 days' follow-up had lower levels of CRP (p=0.03) and ICTP (p=0.01). CONCLUSION:
Inflammation and abnormal indices of matrix degradation pre-EC were not associated with the immediate EC success. Maintenance of sinus rhythm at 1 month was associated with lower CRP and ICTP levels.
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Authors | Vicente Climent, Francisco Marín, Luis Mainar, Vanessa Roldán, Amaya García, Juan Gabriel Martínez, Gregory Y H Lip |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 132
Issue 2
Pg. 227-32
(Feb 20 2009)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 18234374
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Atrial Fibrillation
(blood, immunology, pathology, therapy)
- Chronic Disease
- Cross-Sectional Studies
- Electric Countershock
- Female
- Humans
- Inflammation
- Male
- Prospective Studies
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