Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1).
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| Abstract |
The post-exposure therapeutic efficacy of injectable peramivir against highly pathogenic avian influenza type A H5N1 was evaluated in mice and in ferrets. Seventy to eighty percent of the H5N1-infected peramivir-treated mice, and 70% in the oseltamivir treated mice survived the 15-day study period, as compared to 36% in control (vehicle) group. Ferrets were infected intranasally with H5N1 followed by treatment with multiple doses of peramivir. In two of three trials, a statistically significant increase in survival over a 16-18 day period resulted from peramivir treatment, with improved survival of 40-64% in comparison to mock-treated or untreated animals. Injected peramivir mitigates virus-induced disease, reduces infectious virus titers in the lungs and brains and promotes survival in ferrets infected intranasally with this highly neurovirulent isolate. A single intramuscular peramivir injection protected mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets.
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| Authors | Nadezhda E Yun, Nathaniel S Linde, Michele A Zacks, Ian G Barr, Aeron C Hurt, Jeanon N Smith, Natallia Dziuba, Michael R Holbrook, Lifang Zhang, John M Kilpatrick, C Shane Arnold, Slobodan Paessler |
| Journal | Virology (Virology) Vol. 374 Issue 1 Pg. 198-209 (Apr 25 2008) ISSN: 0042-6822 [Print] United States |
| PMID | 18234269 (Publication Type: Journal Article, Research Support, N.I.H., Extramural) |
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