Sublingual nitroglycerin seems to be effective in the management of retained placenta.

Abstract

BACKGROUND:

A common approach in the management of retained placenta is administration of oxytocin followed by controlled cord traction. Previously it has also been demonstrated that intravenously administered nitroglycerin facilitates manual extraction of retained placenta. The purpose of the present trial was to examine the success rate and safety of sequential administration of intravenous oxytocin in combination with sublingual nitroglycerin for the delivery of retained placenta.

METHODS:

The report is a chart review of 24 women with retained placenta despite intravenously administered oxytocin. The women were given sublingual nitroglycerin (1 mg) to promote detachment of the placenta. Some 5 min after resorption of the tablets, controlled cord traction was carried out for a maximum of 5 min. In addition, changes in blood pressure following treatment with nitroglycerin and total blood loss during delivery were registered.

RESULTS:

Twenty-one of the women delivered the placenta successfully following sublingual administration of nitroglycerin. The procedure failed in 3 women and operative manual removal under regional or general anesthesia was undertaken. No complications due to nitroglycerin were registered.

CONCLUSIONS:

Sequential administration of oxytocin and nitroglycerin seems to be an effective and safe procedure in the management of retained placenta. However, larger studies are needed to confirm the encouraging results of the present trial.

• Authors: Erling Ekerhovd, Maria Bullarbo
• Journal: Acta obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 87 Issue 2 Pg. 222-5 ( 2008) ISSN: 1600-0412 [Electronic] United States
• PMID: 18231892 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oxytocics
• Vasodilator Agents
• Oxytocin
• Nitroglycerin

Topics

• Administration, Sublingual
• Adult
• Drug Therapy, Combination
• Female
• Humans
• Injections, Intramuscular
• Injections, Intravenous
• Nitroglycerin (therapeutic use)
• Oxytocics (therapeutic use)
• Oxytocin (therapeutic use)
• Placenta, Retained (therapy)
• Pregnancy
• Traction
• Vasodilator Agents (therapeutic use)