Abstract | OBJECTIVES: METHODS:
Meningitis was induced by direct inoculation of a clinical strain isolated from an immunocompromised patient (10(7) cfu/mL) into the cisterna magna of New Zealand rabbits. After 16 h of incubation, rabbits were separated into four groups: moxifloxacin (M), ampicillin + gentamicin (A), ampicillin + gentamicin 2 (A2) and control (C). Group M received 20 mg/kg moxifloxacin at the end of the incubation time and 5 h later by intravenous (i.v.) route. Group A received ampicillin (30 mg/kg/h) and gentamicin (2.5 mg/kg/h) by i.v. route with continuous infusion for 8 h in 36 mL of 0.9% NaCl, group A2 received the same dosage of gentamicin and ampicillin in two different 36 mL 0.9% NaCl solutions and group C did not receive any treatment. Cerebrospinal fluid (CSF) samples (0.1-0.25 mL) were obtained 16 and 24 h after induction of meningitis. RESULTS: At the end of the 16 h of incubation, CSF bacterial counts were similar in all groups (P > 0.05). At the final stage of the study (24 h after induction of meningitis), bacterial counts in all treatment groups were significantly lower than the control group (P < 0.05). When the three treatment groups were compared, bacterial counts were found to be similar (P > 0.05). CONCLUSIONS:
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Authors | Oguz Resat Sipahi, Tuncer Turhan, Husnu Pullukcu, Sebnem Calik, Meltem Tasbakan, Hilal Sipahi, Bilgin Arda, Tansu Yamazhan, Sercan Ulusoy |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 61
Issue 3
Pg. 670-3
(Mar 2008)
ISSN: 1460-2091 [Electronic] England |
PMID | 18230687
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aza Compounds
- Fluoroquinolones
- Gentamicins
- Quinolines
- Ampicillin
- Moxifloxacin
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Topics |
- Ampicillin
(administration & dosage)
- Animals
- Aza Compounds
(administration & dosage)
- Disease Models, Animal
- Drug Therapy, Combination
- Fluoroquinolones
- Gentamicins
(administration & dosage)
- Humans
- Male
- Meningitis, Listeria
(drug therapy, microbiology, physiopathology)
- Moxifloxacin
- Quinolines
(administration & dosage)
- Rabbits
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