| Abstract | The aim of the study was to evaluate changes in the arterial wall in children with chronic kidney disease (CKD). We studied 60 patients: 32 with stages 2-4 CKD [chronic renal failure (CRF)], 28 with stage 5 CKD [end-stage renal disease (ESRD)], and 43 controls (C). The evaluated parameters included intima-media thickness (IMT) of the carotid arteries, bone mineral density (BMD), serum lipid levels, and parameters of the calcium-phosphorus metabolism. Patients were divided into two groups: group 1 with normal arteries, and group 2 with arterial changes. The highest serum fetuin A level was found in group 1 compared with groups 2 and C. A negative correlation between IMT and fetuin A level was found. In patients with ESRD, a positive correlation of IMT with phosphorus level and age and a negative correlation with cyclase-activating parathyroid hormone and cyclase inhibiting parathyroid hormone (CAP/CIP) ratio was observed. Multiple linear regression showed that lower fetuin-A and alkaline phosphatase (AP) levels and higher lumbar spine BMD independently predicted higher IMT. Arterial wall changes in children with CKD were related to lower fetuin A and AP level and higher BMD. Low CAP/CIP and high phosphorus level may also be significant factors for arterial changes in patients with ESRD. |
| Authors | Helena Ziolkowska, Michal Brzewski, Maria Roszkowska-Blaim
(Affiliation: Department of Pediatrics and Nephrology, Medical University of Warsaw, Marszałkowska 24, Warsaw, Poland. helenaziolk at op.pl)
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| Journal | Pediatric nephrology (Berlin, Germany)
(Pediatr Nephrol)
Vol. 23
Issue 5
Pg. 805-11
(May 2008)
ISSN: 0931-041X Germany |
| PMID | 18228041
(Publication Type: Comparative Study, Journal Article)
|
| Chemical References |
- Blood Proteins
- alpha2HS glycoprotein
- Phosphorus
- Alkaline Phosphatase
|
| Topics |
- Absorptiometry, Photon
- Adolescent
- Adult
- Alkaline Phosphatase
(blood)
- Blood Proteins
(metabolism)
- Bone Density
- Carotid Arteries
(ultrasonography)
- Child
- Child, Preschool
- Disease Progression
- Female
- Follow-Up Studies
- Humans
- Kidney Failure, Chronic
(complications, metabolism, ultrasonography)
- Lumbar Vertebrae
(radiography)
- Male
- Peripheral Vascular Diseases
(etiology, metabolism, ultrasonography)
- Phosphorus
(metabolism)
- Prognosis
- Risk Factors
- Time Factors
- Tunica Intima
(ultrasonography)
- Ultrasonography, Doppler
|
