[Safety surveillance in the National Vaccination Programme; fewer adverse events with the DTP-IPV-Hib vaccine after the transition to an acellular pertussis component in 2005].

Abstract

OBJECTIVE:

To determine the adverse reactions to the combined vaccine against diptheria, acellular pertussis, tetanus, poliomyelitis and Haemophilus Infuenzae type B (DTP-IPV-Hib) before and after the introduction of an acellular pertussis component.

DESIGN:

Descriptive.

METHOD:

Safety surveillance of the Dutch National Vaccination Programme is performed by the National Institute for Public Health and Environment (RIVM). It is based on an enhanced passive reporting system and complemented by targeted survey-based studies. The data obtained were analysed.

RESULTS:

The passive surveillance system showed a large increase in reports in 2004, probably linked to increased media attention on the efficacy and safety of the whole-cell DTP-IPV-Hib vaccine. The Health Council recommended transitioning to the use of a DTP-IPV-Hib vaccine with an acellular pertussis component, which was implemented in January 2005. The number of reports dropped sharply in 2005 to a level below that of 2002-2003. Results of a survey study on adverse events following DTP-IPV-Hib vaccination that began in late 2003 and continued in 2005 confirmed the wide coverage ofthe enhanced passive surveillance system and revealed low rates of underreporting of rare adverse events, such as collapse and convulsions.

CONCLUSION:

This study confirms the data from the passive surveillance system, which show that the newly introduced acellular DTP-IPV-Hib vaccine is associated with fewer adverse events than the whole-cell vaccine that was used previously.

• Authors: N A T van der Maas, S David, J M Kemmeren, P E Vermeer-de Bondt
• Journal: Nederlands tijdschrift voor geneeskunde (Ned Tijdschr Geneeskd) Vol. 151 Issue 49 Pg. 2732-7 (Dec 08 2007) ISSN: 0028-2162 [Print] Netherlands
• Vernacular Title: Veiligheidsbewaking van Rijksvaccinatieprogramma; minder bijwerkingen van DKTP-Hib-combinatievaccin sinds overgang in 2005 naar vaccin met acellulaire kinkhoestcomponent.
• PMID: 18225797 (Publication Type: English Abstract, Journal Article)

Chemical References

• DTP-IPV-Hib vaccine
• Diphtheria-Tetanus-Pertussis Vaccine
• Diphtheria-Tetanus-acellular Pertussis Vaccines
• Haemophilus Vaccines
• Pertussis Vaccine
• Poliovirus Vaccine, Inactivated
• Vaccines, Combined

Topics

• Adverse Drug Reaction Reporting Systems
• Diphtheria-Tetanus-Pertussis Vaccine
• Diphtheria-Tetanus-acellular Pertussis Vaccines (standards)
• Haemophilus Vaccines
• Humans
• Netherlands
• Pertussis Vaccine (adverse effects, immunology)
• Poliovirus Vaccine, Inactivated
• Population Surveillance
• Risk Factors
• Safety
• Vaccination (standards)
• Vaccines, Combined (adverse effects, immunology)