[Photodynamic therapy for subretinal neovascular membranes. Communication 2. Results of treatment for complicated myopia].

Abstract

The efficiency of photodynamic therapy (PDT) versus drug therapy was evaluated in patients with subretinal neovascular membranes (SNM) in complicated myopia (CM). Photosens (aluminum phthalocyanine) was intravenously injected in a dose of 0.05 mg/kg. The irradiation conditions were as follows: a session was carried out, using a laser at a wavelength of 675 nm, in an exposure light dose of 120 J/cm2. The number of sessions ranged from 3 to 5 a week, depending on the clinical picture of SNM. The total light dose was not greater than 500 J/cm2. Twelve months after drug therapy and a course of PDT, reduced visual acuity was observed in 50% and only 20.8% of cases, respectively. Stabilization or increase of visual functions occurred in the remaining patients receiving a course of PDT.

• Authors: S E Avetisov, M V Budzinskaia, T N Kiseleva, E E Kazarian, I V Gurova, T V Smirnova, I V Shcheglova, E A Privivkova, V B Loshchenov, S A Shevchik, S G Kuz'min, G N Vorozhtsov
• Journal: Vestnik oftalmologii (Vestn Oftalmol) 2007 Nov-Dec Vol. 123 Issue 6 Pg. 8-11 ISSN: 0042-465X [Print] Russia (Federation)
• PMID: 18225516 (Publication Type: English Abstract, Journal Article)

Chemical References

• Indoles
• Organometallic Compounds
• Radiation-Sensitizing Agents
• aluminum tetrasulfophthalocyanine

Topics

• Adult
• Electroretinography
• Fluorescein Angiography
• Follow-Up Studies
• Fundus Oculi
• Humans
• Indoles (administration & dosage, therapeutic use)
• Injections, Intravenous
• Myopia (complications, physiopathology)
• Ophthalmoscopy
• Organometallic Compounds (administration & dosage, therapeutic use)
• Photochemotherapy (methods)
• Radiation-Sensitizing Agents (administration & dosage, therapeutic use)
• Refraction, Ocular
• Retina (pathology, physiopathology)
• Retinal Neovascularization (complications, drug therapy, pathology)
• Treatment Outcome
• Visual Acuity