Effects of goshuyuto on lateralization of pupillary dynamics in headache.

Abstract

Autonomic nervous imbalance is implicated in chronic headache. We investigated the effects of goshuyuto-a representative Kampo medicine for headache-on the lateralization of the pupillary autonomic nervous system by using binocular infrared video pupillography. Patients with chronic headache were administered goshuyuto extract for 1 month (1st stage). Goshuyuto was discontinued for 1 month, following which the patients were randomly divided into 2 groups: placebo and goshuyuto. In the 2nd stage, the respective groups were administered placebo or goshuyuto for 3 months. The average laterality of the pupillary dynamics decreased significantly in the goshuyuto group. These results suggest that the reduction of the difference in pupillary autonomic balance between the left and right eyes might be one of the action mechanisms of goshuyuto to relieve chronic headache.

• Authors: Akino Wakasugi, Hiroshi Odaguchi, Tetsuro Oikawa, Toshihiko Hanawa
• Journal: Autonomic neuroscience : basic & clinical (Auton Neurosci) Vol. 139 Issue 1-2 Pg. 9-14 (May 30 2008) ISSN: 1566-0702 [Print] Netherlands
• PMID: 18222735 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Drugs, Chinese Herbal

Topics

• Adolescent
• Adult
• Aged
• Child
• Double-Blind Method
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Functional Laterality (physiology)
• Headache Disorders (drug therapy, physiopathology)
• Humans
• Male
• Medicine, Kampo
• Middle Aged
• Reflex, Pupillary (drug effects)
• Severity of Illness Index
• Surveys and Questionnaires