Abstract | BACKGROUND: METHODS: After a systematic review of English language studies, sensitivity, specificity, and other measures of accuracy of ADA concentration in the diagnosis of pleural effusion were pooled using random effects models. Summary receiver operating characteristic curves were used to summarize overall test performance. RESULTS: Sixty-three studies met our inclusion criteria. The summary estimates for ADA in the diagnosis of tuberculous pleurisy in the studies included were sensitivity 0.92 (95% confidence interval 0.90-0.93), specificity 0.90 (95% confidence interval 0.89-0.91), positive likelihood ratio 9.03 (95% confidence interval 7.19-11.35), negative likelihood ratio 0.10 (95% confidence interval 0.07-0.14), and diagnostic odds ratio 110.08 (95% confidence interval 69.96-173.20). CONCLUSIONS: ADA determination is a relative sensitive and specific test for the diagnosis of tuberculous pleurisy. Measurement of ADA in pleural effusion is thus likely to be a useful diagnostic tool for tuberculous pleurisy. The results of ADA assays should be interpreted in parallel with clinical findings and the results of conventional tests.
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Authors | Qiu-Li Liang, Huan-Zhong Shi, Ke Wang, Shou-Ming Qin, Xue-Jun Qin |
Journal | Respiratory medicine
(Respir Med)
Vol. 102
Issue 5
Pg. 744-54
(May 2008)
ISSN: 0954-6111 [Print] England |
PMID | 18222681
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
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Chemical References |
- Biomarkers
- Adenosine Deaminase
|
Topics |
- Adenosine Deaminase
(analysis)
- Biomarkers
(analysis)
- Clinical Enzyme Tests
- Humans
- Mycobacterium tuberculosis
- Odds Ratio
- Pleural Effusion
(enzymology)
- ROC Curve
- Sensitivity and Specificity
- Tuberculosis, Pleural
(diagnosis)
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