Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding.

Abstract

Acute promyelocytic leukemia (APL) is characterized by chromosomal rearrangements of 17q21, leading to fusion of the gene-encoding retinoic acid receptor alpha (RARA) with a number of alternative partner genes. Signal transducer and activator of transcription 5 beta (STAT5B) is one of the alternative partners. We report a rare case of APL with STAT5B-RARA fusion transcript and the normal chromosome 17 on G-banding. Administration of all trans-retinoic acid improved disseminated intravascular coagulation without decrease of the leukemia cells in his peripheral blood and bone marrow. The molecular mechanism of fusion between STAT5B and RARA by chromosomal rearrangement is discussed based on the data from genome database. Clinical characteristics of APL with STAT5B-RARA are also discussed.

• Authors: Manabu Kusakabe, Kazumi Suzukawa, Toru Nanmoku, Naoshi Obara, Yasushi Okoshi, Harumi Y Mukai, Yuichi Hasegawa, Hiroshi Kojima, Yasushi Kawakami, Haruhiko Ninomiya, Toshiro Nagasawa
• Journal: European journal of haematology (Eur J Haematol) Vol. 80 Issue 5 Pg. 444-7 (May 2008) ISSN: 1600-0609 [Electronic] England
• PMID: 18221386 (Publication Type: Case Reports, Journal Article)

Chemical References

• Oncogene Proteins, Fusion
• STAT5 Transcription Factor
• STAT5-RARalpha protein, human

Topics

• Adult
• Aged
• Amino Acid Sequence
• Base Sequence
• Chromosomes, Human, Pair 17 (genetics)
• Humans
• Karyotyping
• Leukemia, Promyelocytic, Acute (genetics)
• Male
• Middle Aged
• Molecular Sequence Data
• Oncogene Proteins, Fusion (analysis, chemistry, genetics)
• STAT5 Transcription Factor (analysis, chemistry, genetics)
• Transcription, Genetic (genetics)