99mTc-N-DBODC5: a novel myocardial perfusion imaging agent for diagnosis of coronary artery disease, a review.

Abstract

In myocardial SPECT imaging with the popularly used 99mTc-sestamibi and 99mTc-tetrofosmin, intense liver uptake leads to a paradoxical decrease of counts in the absence of perfusion abnormalities, making it difficult to assess myocardial perfusion, particularly in the inferior or inferoapical left ventricular wall. 99mTc-N-DBODC5, which is a new lipophilic, mono-cationic nitride myocardial perfusion imaging agent, exhibits high myocardial uptake and excellent bio-distribution kinetics with rapid liver clearance in rats and dogs. 99mTc-N-DBODC5 myocardial imaging during vasodilator stress can determine the severity of stenosis, though underestimates occur with mild coronary stenosis compared to 201Tl, in a similar way to what occurs with 99mTc-sestamibi and 99mTc-tetrofosmin. In particular, 99mTc-N-DBODC5's rapid liver clearance, which may significantly reduce the photon scatter from the liver, allows for the reduction of artifactual decreased myocardial perfusion and the improvement of the diagnostic accuracy of coronary artery disease.

• Authors: Tohoru Takeda, Jin Wu, Thet-Thet Lwin
• Journal: Recent patents on cardiovascular drug discovery (Recent Pat Cardiovasc Drug Discov) Vol. 1 Issue 2 Pg. 161-6 (Jun 2006) United Arab Emirates
• PMID: 18221083 (Publication Type: Journal Article, Review)

Chemical References

• 99mTc-N-DBODC5
• Organophosphorus Compounds
• Organotechnetium Compounds
• technetium tc-99m tetrofosmin
• Technetium Tc 99m Sestamibi

Topics

• Animals
• Coronary Artery Disease (diagnostic imaging)
• Coronary Circulation
• Coronary Stenosis (diagnostic imaging)
• Dogs
• Heart (diagnostic imaging)
• Humans
• Liver (diagnostic imaging)
• Organophosphorus Compounds (pharmacokinetics)
• Organotechnetium Compounds (pharmacokinetics)
• Technetium Tc 99m Sestamibi (pharmacokinetics)
• Tissue Distribution
• Tomography, Emission-Computed, Single-Photon