Tetraspanins-structural and signalling scaffolds that regulate platelet function.

Abstract	There are several tetraspanins present in platelets including CD9, CD151, TSSC6, and CD63. Recent studies in knockout mouse models have revealed that CD151 and TSSC6 are physically and functionally involved in regulation of the 'outside-in' signalling properties of the major platelet integrin, integrin alpha(IIb)beta(3) and thrombus stability in vivo.
Authors	Matt W Goschnick, Denise E Jackson
Journal	Mini reviews in medicinal chemistry (Mini Rev Med Chem) Vol. 7 Issue 12 Pg. 1248-54 (Dec 2007) ISSN: 1389-5575 [Print] Netherlands
PMID	18220977 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	Membrane Proteins
Topics	Animals Blood Platelets (cytology) Humans Membrane Proteins (chemistry, metabolism, physiology) Signal Transduction

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