| Abstract | Hepatic arterial infusion (HAI) chemotherapy is one of the strategies for cases in poor performance status. This is a case report of multiple liver metastases from rectal cancer in poor performance status successfully treated with HAI plus CPT-11. A 59-year-old man who had rectal cancer, multiple liver metastases and para-aortic LN metastasis underwent a laparoscopic rectal anterior resection. He denied receiving postoperative chemotherapy and selected alternative therapy at another clinic. Four months later, he visited our hospital. His liver metastasis and performance status got worse, so HAI of 5-FU 1250 mg/m2 for 5-hour weekly (weekly high-dose 5-FU: WHF) was started at first. After 3 courses, his status improved, so systemic chemotherapy was added. HAI (WHF: 1000 mg/m2) plus CPT-11 (100 mg/m2) was effective, and liver metastases showed a significant reduction (PR) on abdominal CT. HAI plus CPT-11 was effective for a patient of the poor performance status with unresectable liver metastasis. |
| Authors | Yoshihito Ide, Kazuyuki Okada, Hideo Ohta, Kentaro Maruyama, Hideoki Yokouchi, Masakatsu Kinuta, Taku Yasumoto, Kohei Murata
(Affiliation: Dept. of Surgery, Suita Municipal Hospital.)
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| Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 34
Issue 12
Pg. 2059-61
(Nov 2007)
ISSN: 0385-0684 Japan |
| PMID | 18219898
(Publication Type: Case Reports, English Abstract, Journal Article)
|
| Chemical References |
- Tumor Markers, Biological
- irinotecan
- Fluorouracil
- Camptothecin
|
| Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Camptothecin
(administration & dosage, analogs & derivatives, therapeutic use)
- Fluorouracil
(administration & dosage, therapeutic use)
- Humans
- Infusions, Intra-Arterial
- Liver Neoplasms
(blood, drug therapy, pathology, secondary)
- Male
- Middle Aged
- Rectal Neoplasms
(blood, drug therapy, pathology, surgery)
- Tomography, X-Ray Computed
- Tumor Markers, Biological
(blood)
|
